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There is rare information in the literature regarding direct small bowel involvement of Waldenstrom macroglobulinemia. A 52-year-old male was admitted to the hospital with complaints of spleen mass and diarrhea and was diagnosed with lymphoma after splenectomy. In the upper gastrointestinal system, endoscopy performed due to watery diarrhea 8-10 times a day, no pathological findings were detected in the esophagus and stomach, but white nodular formations 1-2 mm in diameter were observed, covering almost the entire mucosa, combined with each other and continuous in the bulbus, second and third parts of duodenum. In the sample taken from the duodenum, it was noted that some of these deposits were located inside the lymphatics. In the histochemical examination, it was observed that the deposits were not stained with Congo red, they were stained red with Masson’s trichrome, and in the immunohistochemical examination, lambda and immunoglobulin M were positive and immunoglobulin G, immunoglobulin A, and kappa were negative. In ileocolonoscopy, the cecum was normal, the same lesions in the duodenum were observed in the terminal ileum, and the biopsy result was also reported as immunoglobulin M lambda deposits in the epithelium. The case was evaluated as small bowel involvement of Waldenstrom macroglobulinemia.
Cite this article as: Uysal A, Doğanavşargil B, Özsan N, Harman M, Turan İ, Oruç N. Small bowel involvement of waldenstrom macroglobulinemia: A case report. Diagn Interv Endosc. 2022;1(2):48-52.